Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.
Identifieur interne : 002976 ( Main/Exploration ); précédent : 002975; suivant : 002977Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.
Auteurs : Thomas J. Montine [États-Unis] ; Ke Li ; Daniel P. Perl ; Douglas GalaskoSource :
- Neurology [ 1526-632X ] ; 2005.
Descripteurs français
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (chemically induced), Alzheimer Disease (metabolism), Alzheimer Disease (physiopathology), Amino Acids, Diamino (analysis), Amino Acids, Diamino (metabolism), Amyotrophic Lateral Sclerosis (chemically induced), Amyotrophic Lateral Sclerosis (metabolism), Amyotrophic Lateral Sclerosis (physiopathology), Brain (metabolism), Brain (pathology), Brain (physiopathology), Brain Chemistry (physiology), Canada, Environmental Exposure, Female, Guam, Humans, Male, Middle Aged, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (physiopathology), Reproducibility of Results.
- MESH :
- chemical , analysis : Amino Acids, Diamino.
- geographic : Canada, Guam.
- chemically induced : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Parkinsonian Disorders.
- metabolism : Alzheimer Disease, Amino Acids, Diamino, Amyotrophic Lateral Sclerosis, Brain, Parkinsonian Disorders.
- pathology : Brain.
- physiology : Brain Chemistry.
- physiopathology : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Parkinsonian Disorders.
- Aged, Environmental Exposure, Female, Humans, Male, Middle Aged, Reproducibility of Results.
Abstract
High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.
DOI: 10.1212/01.wnl.0000174523.62022.52
PubMed: 16157919
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.</div>
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<name sortKey="Li, Ke" sort="Li, Ke" uniqKey="Li K" first="Ke" last="Li">Ke Li</name>
<name sortKey="Perl, Daniel P" sort="Perl, Daniel P" uniqKey="Perl D" first="Daniel P" last="Perl">Daniel P. Perl</name>
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<country name="États-Unis"><region name="Washington (État)"><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
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